Metered Dose Inhaler

Metered Dose Inhaler - In this blog, we are going to cover all the information regarding “Metered Dose Inhaler”. Inhalers are common these days and the demand is getting high with each year passing. India struggles with increasing pollution and improving healthcare infrastructure. Also, the global market of MDI is in billions and it is one of the profitable segments within the pharma industry.

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The main reasons behind the rising respiratory illnesses are the rising air pollution levels. Especially, In India, there is a rising demand for inhalers as we are among the top countries with the highest number of asthma patients. Not only elderly patient numbers are high but even children suffering from asthma are quite high in India. 

Metered Dose Inhaler Market Size | The Increasing Demand For Inhalers

The Inhaler market is increasing with a CAGR rate of 7.3% and the current market value is over $1.2 billion. There are some major reasons behind this surge in demand for inhalers in the market. As per the global data, the projection for the coming five years is Rs. 2,261.1 million.  If we particularly consider the demand for metered dose inhalers in India, then there are some prominent factors such as-

1. The growing cases of respiratory diseases such as asthma, COPD, and allergies.
2. Developing healthcare infrastructure
3. Increasing awareness regarding respiratory illnesses among Indians.
4. Rise of air pollution levels in India. 

Moreover, there are over 30 million COPD patients, and approx. 20 million asthma patients in India. There is an undeclared medical emergency for respiratory disease in India. 

What are Metered Dose Inhalers and their Types?

Inhalers or Metered dose inhalers are used for directly delivering the medication to the respiratory organ (lungs) via inhalation/nasal cavity. It is easy to use and consists of an aerosol canister. In the current market, there are different types of MDI available having different applications. Did you know? The first Metered Dose inhaler was developed by Riker Laboratories in 1955. However, there are three main components of an inhaler - 

1. The canister is made from aluminum/stainless steel
2. The metering valve 
3. An actuator or mouthpiece 

But sometimes inhalers came with an additional device known as holding chambers or spacers used for reducing the speed of aerosol leaving the canister. Now, let’s take a look into the different categories of metered dose inhalers- 

1. Spacer with Metered dose inhaler -This type of MDI comes with a corticosteroid drug that acts by repressing the overacting immune system for reducing inflammation in the lungs. It comes with a spacer that is put in front of the mouthpiece and has the sole purpose of reducing aerosol speed. Its main function is to relax the lung muscle and provide relief from coughing, asthma, and COPD.
2. Bronchodilators - Drugs such as salmeterol and formoterol come under the category of bronchodilators. The main function of this inhaler is to relax the muscles of the lungs and airways. However, there are two kinds of bronchodilators - short-acting bronchodilators and long-acting bronchodilators. Also, these inhalers are used for treating bronchospasm and are commonly referred to as “rescue inhalers”. 
3. Combination Inhalers - This combination of metered dose inhalers consists of a long-acting bronchodilator and a corticosteroid. It helps in overcoming the side effect of long-acting bronchodilators such as the risk of a heart attack. However, it should not be withdrawn without prior discussion with the doctor.

Working Principle Of Metered Dose Inhalers

As we discussed above regarding the parts of an inhaler. The aluminum/stainless steel contains the medication in liquid form. The technique used here is the Proper technique. A pressurized canister help in delivering the medication to the nasal cavity via inhaling aerosol solution/droplets. When a patient pushes the canister, it pushes a button on the other end. So, via metered valve and mouthpiece, the medication reached the nasal cavity. Here, the pressure and medication present in the canister are important for quick relief from coughing, shortness of breath, etc. At last,  the motive for inhaling via the nasal cavity is because the cavity is rich in blood vessels and increases the absorption rate which is quite important for medical conditions like asthma, COPD, bronchospasm, allergies, etc. 

Metered Dose Inhalers Available At Nutra Respiro

#1 Budesonide I.P. 200 µg Formoterol Fumarate Dihydrate I.P.6 µg Inhaler

This inhaler is available in the market with the brand name “ Budased F 200” and the cost is Rs.359.  It comes under the category of bronchodilators. The main medical usage of these inhalers is for the treatment of COPD (chronic obstructive pulmonary disease) and emphysema. It consists of two chemicals named Budesonide and Formoterol. Here, 

Budesonide comes under the category of corticosteroid drug class and it helps in reducing irritation & swelling in the nasal cavity. Whereas Formoterol is a type of long-acting beta-agonist class drug that helps in relaxing the muscles and also has anti-inflammatory properties. Furthermore, there are some other medical uses of Budesonide Formoterol Fumarate Dihydrate inhalers which includes curing shortness of breath, cough, discomfort, chest tightness, etc. 

Some common side effects of Budesonide Formoterol Fumarate Dihydrate MDI are inflammation of the sinuses, headaches, upset stomach, throat irritation, high B.P., worsening withdrawal symptoms of cough, asthma, etc. 

#2 Ipratropium Bromide Levosalbutamol Inhaler 250 mcg & 50 mcg Inhaler 

Nutra Respiro’s Ipratropium Bromide Levosalbutamol inhaler is available with the brand name “ Persep”. This inhaler is mainly used for the treatment of chronic obstructive pulmonary disease (COPD) and the pricing starts at Rs. 390. Also, it can be applicable for treating bronchospasm. Two main chemicals are being utilized -

Levosalbutamol sulphate comes under the category of beta2-adrenergic agonist. Its main function is to relax the airway’s muscles and it acts as a functional antagonist. The other chemical is Ipratropium Bromide which is an anticholinergic bronchodilatory. An inhibitor of vagally-mediated reflexes that helps in relaxing the muscles of respiratory organs. 

There are some side effects of prolonged use of Ipratropium Bromide Levosalbutamol Inhalers such as dry mouth, headache, asthma, dizziness, vomiting, allergies, inflammation, and many more. 

#3 Fluticasone Propionate 250mcg Salmeterol 25mg Inhaler  

A steroid inhaler Fluticasone-Salmeterol used for treating asthma and can be an effective treatment for Chronic Obstructive Pulmonary Disease (COPD). Also, this inhaler is applicable for long-term as well as a short-term treatment of asthma. Here, Fluticasone is a steroid that helps in preventing inflammation in the nasal cavity whereas Salmeterol comes under the category of bronchodilator. However, this inhaler has some side effects, such as fungal infection and blurred vision. Pain, allergies, shortness of breath, fever, chills, etc. Fluticasone Propionate Salmeterol inhaler is available in the market with the brand name “ Nutiflo-S 250”. 

Direction To Use | How to Use Metered Dose Inhaler?

Firstly, we will cover the step to properly use the metered-dose inhaler with a valved holding chamber. 

1. First of all,  priming which means spraying 1 or 2  puffs into the air. This is done for making sure that the inhaler is ready to use and is working well. 
2. Now, remove the cap and shake it well.
3. Put the valved chamber on the inhaler.
4. Then, put the mouthpiece in between your teeth and close your lips.
5. Breathe out fully and press the canister only once.
6. Now, breathe slowly and make sure you are not making a “horn-like” sound. 
7. Hold your breath for 10 seconds. So that medication from the inhaler reaches the lungs. 
8. Keep at least 1 minute of a break between each puff and repeat the steps mentioned above.

Now, the steps to use a metered-dose inhaler without any chamber

1. Start by removing the cap and shaking for 5 seconds.
2. Breathe out and put the mouthpiece between your teeth and seal the mouth with your lips. 
3. Slowly breathe out and press the canister.
4. It will take only 5 seconds for the medication to reach the lungs. 
5. Repeat the same steps for other puffs but make sure to wait for 1 minute.

Things need to be Remember | Use of Metered Dose Inhaler

1. Replace the cap after application.
2. If you are using a steroid inhaler, then rinse your mouth with or without mouthwash after use.
3. Always use halved chamber if it's a steroid inhaler.
4. Once a week clean the plastic holder in running warm water to prevent any clogging.
5. If the plastic holder cannot be removed then widen it with a clean napkin or cotton. 
6. Do not store halve chamber in a plastic container.
7. Keep the track of total puffs and remaining puffs.
8. Do not stop using the inhaler without prior discussion with the doctor. 

About | The Leading Respiratory Products Pharma Company - Nutra Respiro 

Nutra Respiro is the leading pharmaceutical company that deals in respiratory product franchises in India. The company has the ISO-certified metered dose inhaler range. Not only that, there is a premium range of respules, nasal sprays, n-acetylcysteine tablets, anti-allergy bronchodilators, anti-cold & general range. However, our company “Nutra Respiro” started with a mission of providing the best quality pharma products for patients suffering from respiratory illnesses. Also, the entire range of MDI and other products are manufactured on their premises having state-of-the-art infrastructure. Our facility for the PCD Pharma Franchise is available across all the states of India. 

Conclusion

Lastly, hope you get all the information regarding the “Metered Dose Inhaler”. Being 2nd most populated country, the demand for MDI is increasing each year as people are facing respiratory diseases like asthma, COPD, and allergies as the increasing rate of pollution. However, if you have any queries, feel free to reach out to us!

Frequently Asked Questions (FAQ)

Question - What are the uses of metered dose inhalers?

Answer - The main usage of MDI is for treating asthma, COPD, allergies, bronchospasm, etc.

Question - Which company is the best for metered dose inhalers range in India? 

Answer - Nutra Respiro is one of the leading pharma companies having the best-metered dose inhaler range in India.